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rich in gallic acid) indicated the activation of PPAR and carnitine palmitoyl transferase (involved in lipid oxidation) [45]

Moreover, in the lungs of mutant mice in which CLOCK expression is disrupted (Clock 19 mice ), the rhythmic expression of NRF2 protein was lost along with reduced GCL mRNA expression and lower levels of GSH resulting in increased oxidative damage (17), demonstrating a link between the circadian clock, the NRF2/GSH pathways and protection from oxidative stress

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The validated data then passed through several rounds of quality control to remove errors and inconsistencies, so the final numbers reflect a consistent and defensible view of the market

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However, the underlying molecular mechanism needs to be further elucidated